In the year 2022, the vampire Louis de Pointe du Lac tells the story of his life to renown journalist Daniel Molloy. Beginning in 1910 New Orleans, Louis forms a vampire family with the vampire Lestat, complete with teen fledgling, Claudia.
Rowan Fielding, an intuitive young neurosurgeon, discovers that she is the unlikely heir to a family of witches. As she grapples with her newfound powers, she must contend with a sinister presence that has haunted her family for generations.