U.S. Marshal Teddy Daniels and his partner Chuck Aule begin to fear for their own lives and sanity when their investigation on Shutter Island into how a patient escaped the Ashcliffe Hospital for the Criminally Insane yields more questions than answers.
Conceived to provide a bone marrow match for her leukemia-stricken sister, teenage Kate begins to question her moral obligations in light of countless medical procedures and decides to fight for the right to make decisions about her own body.